I actually disabled my side buttons because I was accidentally pressing them while picking up the mouse (while holding a click). I'm much happier now that I've done that.
I've had the problem with the sticky ball. It gets to where it will scroll up but not down, or down and not up. Holding it upside down while spraying condensed air at the ball or holding it upside down and wiping down the ball with a clean cloth seem to work. When they don't, restarting the computer helps. (I half think it's a software issue and that the holding upside down part has more to do with it resetting than actually removing gook, but when you find a series of steps that works, I guess knowing which ones don't contribute isn't really important.)