The AKiTiO Node uses Texas Instrument TPS65983 USB-C/Thunderbolt controller which is fully compatible with macOS and 2016 MacBook Pro. Problem is there's a software block in macOS to prevent eGPU from working through this very controller. I confirmed this by trying a PCIe Flash SSD which works immediately. No luck with a graphics card.
Apple went as far as rolling out Thunderbolt 3 enclosure block on all Thunderbolt equipped Macs with the latest macOS 10.12.2. This means Razer Core, AKiTiO Thunder3 which have the older TPS65982 controller will show the Unsupported message not only on 2016 MacBook Pros but also on all Thunderbolt Macs. There's currently a workaround for this TPS65982 TB3 enclosure block (discovered by kid2010 on netkas).
I really hope Apple would allow eGPU in its next update or the eGPU community can find a workaround soon. My 2016 MacBook Pro works great with this AKiTiO Node in Windows 10. This eGPU setup is running with a GTX 980 Ti Hybrid and able to power the internal display. Check out Valley benchmark video
here.
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You can use Apple Thunderbolt 3 to Thunderbolt 2 adapter. However, it won't work in macOS atm due to Apple's restriction mentioned above. It may work in Windows 10. I'd recommend going with the AKiTiO Thunder2 for older Macs. If you plan on future proofing your eGPU enclosure, go with the Thunder3. I've used it successfully with a 2015 11" MBA and 2011 17" MacBook Pro via the TB3<-->TB2 adapter. It even works in Windows 10.