Back in 2002 I saw a Mac Plus being used in the University of Iowa main library's shipping department. It appeared to be running an ancient version of Microsoft Excel.
I'm more into Apple IIs than Macs, and I've seen some evidence of them in the wild. The Apple II's expandability made it an early favorite of scientists who needed to interface it with a variety of instruments, and it seems it's still hanging around. Examples:
An Apple II Plus (manufactured 1979-1983) being used at Dartmouth for lower-level physics labs:
http://www.dartmouth.edu/~physics/labs/descriptions/ball.spring.html
http://www.dartmouth.edu/~physics/labs/descriptions/projectile.motion.html
The pages are dated 5/21/2004 and 6/16/2004. Identified in the equipment list:
1 Apple II+ computer
2 monitors
1 video camera
1 imagewriter printer/paper
2 AppleStrobe software disks
An Apple IIe (from the look of it, a pre-Platinum model, which would place it 1983-1986), being used with a Finnigan MAT-251 mass spectrometer at the Earth Systems Center for Stable Isotopic Studies at Yale:
http://earth.geology.yale.edu/escsis/escsis2006.ppt (PowerPoint file - page 3 shows the setup)
It seems the Apple IIe was the standard controller for the MAT-251. They had this setup as of 2006, but their homepage now notes: "The system has been retired and cannibalized long ago."
Another Apple IIe, used with another mass spectrometer, at the Trofimuk United Institute of Geology in Novosibirsk, Russia:
http://list.uvm.edu/cgi-bin/wa?A2=ind0512&L=ISOGEOCHEM&P=R6818
The post is dated 12/15/2005:
We have some troble with Apple IIe computer which is operating of MAT
Delta mass-spec.
Only symptom is blinking of all leds, including leds in floppy slots, in
keyboard and power on led inside the computer.
Power unit was checked and is Ok.
Any advise will be highly appreciated.
Six days later, he fixes it the old-fashioned way:
http://list.uvm.edu/cgi-bin/wa?A2=ind0512&L=ISOGEOCHEM&P=R8422
On case anybody still playng with such old machine.
Symptoms: nothing working. All leds are blinking. Screen is also
blinking. Power unit looks Ok. Live looks horrible.
Solution: do not believe to your tester!!! Replace ALL electrolytic
capacitors in Power unit.
Strictly speaking, I doubt it was necessary to replace
all the capacitors, but as someone that still goofs around with a soldering iron, I was gratified to see him doing this level of repair.
I'd bet money on the Russian Apple IIe still being in use!