My girlfriend is a nurse and uses a Palm Tungsten E2 with the Nursing Central software from Unbound Medicine. She uses it mainly for looking up medications, lab values, etc. but also as an address book, calendar. It synced perfectly with my old iBook G3 running Panther, and transitioned smoothly to our new iMac with Leopard. Prior to getting this model, she had a Palm Z22 which synced fine with the iBook, but did not have enough storage capacity to run the Nursing Central software.