I do.
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I need to be able to access my watch while in sports - but my right hand is busy holding on to my gear. So, even though I'm right-handed, this is how I have to wear it. Honestly, it works great. Reach over, thumb on the bottom right corner, index finger for crown works perfectly.
However. There can be issues wearing this watch where the crown is on the same side as your wrist.
I sometimes need to wear gloves, and depending on the style - they can push the crown in. This might just activate the watch - or if it's a longer press activate Siri. Also, putting your hands into pants pockets etc can have the same effect of pressing the crown with tight pants etc.
Honestly - this is all first world problems.
Works great, go for it!
PS - I find it easier to control the crown with 1 finger using my index finger rather than my thumb - so having the crown on the upper side wouldn't be as good regardless...