Can I move an application from the current using drive to another?

[Mic'sBook]

As the title said.
I ask this question because I watched this:

Macintosh Or Windows? 1996 - YouTube
http://www.youtube.com/watch?v=eUoijkaXBP0
*watch it from 05:46

I know it's talking about classic Mac OS and has nothing to do with Mac OS X in any way, shape or form. Just curious only. Thanks.

 

[miles01110]

Depends on the application.

 

[GGJstudios]

Some applications may not function or update properly if they're moved from the /Applications folder on your boot drive. It's usually a good idea to leave them where they are.