I'm using it on Sequoia, and I'm set up like a developer, with every macOS version installed. No trouble booting into anything from High Sierra to Sequoia, including Mojave. From either M.2 - I'm using sticks from Silicon Power (2TB P34A60) and Addlink (4TB S95).
The 10 Gb USB-c ports both work fine.
Anomaly #1: OCLP makes the 10Gb ethernet port fully work in Monterey, possibly earlier. But the driver OCLP 2.2.0 provides prevents boot in Ventura or later. You have to either use Monterey,
or edit config.plist to disable the driver. After which the 10Gb ethernet port will not work. Not even as a gigabit port.
Anomaly #2: the firmware boot picker hangs when my McFiver is installed - the volume icons never appear. You have to use the OCLP boot picker and/or use Startup Disk to switch volumes. I haven't finished diagnosing this - it could be one of my M.2 sticks, rather than the card. Sonnet lists the Silicon Power P34A60 as "not compatible with macOS", but it worked fine for me. Both in a standalone PCIe adapter (firmware boot picker appears) and in the McFiver (no firmware boot picker).