I have been using the Case-Mate Tough Case for two weeks now. It is well made, and the fit is really good. As Edking said, the strip that runs below the Home button is flexible, but it is not a problem unless you intentionally try to break it. The hole for the headphone jack is pretty big, and the cutout for the USB connector is big enough to accommodate an aftermarket connector cord that am using. This case doesn't have screen protection like the Otterbox Defender, but it does have a thick and stiff rim around the edge of phone so the screen won't make contact with the surface should you place the phone face down.
Because I like this case so much, I canceled my Otterbox Commuter pre-order though Amazon/Beach Camera.