Personally, I wouldn't risk damaging the device just to get some dust out. Dust and debris are much less obtrusive than many people think. Unless you live in an extremely dusty environment such as close to a major construction site, downtown Manhattan, or in close proximity to a desert (not to be confused with close proximity to a dessert, which is much safer for your iMac but less so for your waistline) it is more likely than not a total waste of time. Cleaning out the bottom vents will give you 95% of the effect at 5% the effort and time investment.
However, if you still insist on opening it you need to make sure to get good quality adhesive strips. Unlike
@chscag I've heard terrible things about the OWC kit and mostly good things about the iFixit kit. With that said you can get OEM adhesive strips on eBay that are supposed to be better than both of those. Depending on what configuration iMac you have you may also want to consider upgrading your internal hard drive to a SATA SSD or maybe even Apple's SSD blade to a much larger Samsung NVMe SSD while you're already in there. Don't bother with replacing the thermal compound though as that will most certainly be an utter and complete waste of time and money.