With these new batteries you should never try and run your battery down with every single charge.
It is true that Apple recommends that you drain it all the way and
charge it to 100% once a month.
They do not have a memory but they are good for only so many "complete cycle" charges. Usually about 400. This does not mean you can only charge it 400 times, but only 400 "complete cycles" so if your battery is at 50% and you charge it up to 100% it will only use 0.5 of a cycle. For more info check
out this link.
So what do I do? I ALWAYS try to have my phone plugged in if I am in my Car or by my computer. I only let it run on its battery when it needs to, but I do try and let it go down all the way at least once a month like Apple Recommends. Why waste your charge cycles when you can have it plugged in while you are working on your computer. Having it plugged it most of the time will make the battery last a lot longer and since it is a pain in the ARSE to swap batteries, this will go a long way.
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