As long as the speed of the RAM matches and is the right type then you have no real issues with compatibility, this used to be a problem but these days it isn't since the Memory support is based on the processor not the motherboard.
If you have 2 DIMM slots free it'd be better to go with a 2x4GB kit however as this would allow you to have dual channel memory having 3 slots populated with one free is not as good as having 4 slots populated.