Which EPROM devices do you need to program? Be specific.
Many device programmers have a serial interface. You first plug in a USB-to-serial converter to your Mac, add the drivers for it, and you then have a serial port on the Mac. With the serial port open, you can communicate with any other serial device, as long as you have software.
ZTerm is an example of Mac software that communicates over serial ports:
http://en.wikipedia.org/wiki/ZTerm
There are many others.
There aren't a lot of EPROM programmers that will include Mac software. As a first guess, I'd say none.
If by "EPROM programmer" you actually meant a programmer for microcontrollers with flash memory, then Arduino is certainly Mac-compatible and has Mac software. There are other devices, too.
Frankly, there aren't a lot of old-style UV-erasable EPROMs being used any more. You could probably find some old stockpiles of devices, but most of the technology is at least electrically erasable, and frequently in-system reprogrammable, too. Or it's one-time programmable (OTP).
So it depends on exactly which devices you need to program, and what you're doing with them.