Question is, what does the OP need to backup frequently ?
If several TB worth of data are being used and modified all the time, and thus reqire frequent backups, then that sounds like professional video or audio editing.
External (e)SATA Raid systems seem to be the logical choice, no ?
Say it's just about ripped DVDs or such, then it doesn't seem to make much sense to store all that internally and use precious drive bay space as a data morgue. But to each his own.
However, in that case a Drobo might actually make sense in the long run, if the OP is going to need more space than a bunch of 100$ 1TB external drives deliver in the near future.
But , if you have read the original posting, the OP appears to want to backup several 1TB internal drives without having to buy several additional external drives, which doesn't make much sense, now does it ?
Apart from that, suggesting Drobo is the one and only solution for yet to be determined backup needs is not constructive, it's merely advertising a personal preference of a niche product .
Drobo might not be there any more next year, and there goes your support, expandability and possibly compatibility.
Or maybe it becomes the next industry standard, but I'm not holding my breath .
So right now, imho, the safest, most future-proof and fastest multi-drive backup solution might be an eSATA or FW enclosure , for eSATA hot-swappable and with port multiplication, attached to a cheap SATA-eSATA/ODD port bracket.
Goes for the same as a Drobo.