Well, I actually haven't had any problems at all but I just got the thing today. I have several friends who have external firewire drives and none of them have ever had problems (all on OS 10.3.2) except one who had accidentally not pushed the pins all the way in on the IDE connector for the firewire enclosure around his HD. I was just wondering about disk speed.
Actually, now that I have more space on my hard drive, my computer in general seems smoother and less strained, like actual burden has been lifted off of it. This is technically incorrect, I know, but the placebo is marvelous. While before the extra drive I still had plenty of room for virtual memory, I wonder if there is any substantiation to a generally faster drive with less used capacity (disk defragmentation aside)?
Anyway, good luck with your problems as they sound nasty. What computer are you using? I've heard significant reports of problems with Apple's latest portable line and last generation iBook G3s, but I'm at a university so that's pretty much all that anyone has anyway.