Hello there!
If you have a game like Skyrim, is it better to save all your progress under one save file or save every time you accomplish a mission. That is, you have 1 save file vs 100 save files.
I rotate over 3 or 4. That way you have a bit of a backup in case something goes wrong and it doesn't take much space. On the PS3 my Skyrim saves are taking up 6mb each and you can easily end up with hundreds if you save after every quest. So space can become an issue.