Line spacing, margins and general layout on the cover page is not working for me at all.
It looks too "pat", and the titles are falling off the page visually.
The reflection effect on the inner cover is totally out of place here.
Keep the document clean and free from gimmicky web 2.0 junk.
Nice job on the gimmicky web 2.0 junk though
Font for the body copy is a bit too ornate IMO; I would choose something conservative and clean like 9pt Myriad Pro or Helvetica.
I like the header font and overall layout/color scheme; seems appropriate for the content.
Columns are generally too close together and ragged looking.
Try using full justification and a bit more negative space.
You can tweak the letter spacing and glyphs, and enable hyphenation to minimize rivers in your justified text blocks.
Also the paragraph spacing looks a bit suspect; use paragraph spacing rather than hard-returns, if this is the case.
The juxtaposition between text blocks, headers and images is not quite working with the negative space on pages 8-9.
Try to shape the negative space interestingly with your content.
The pages are begging for some graphical hooks; even a simple thin stroke to unify the content and thread the entire publication would be effective.
I like the little triangle arrow thingies in the captions on page 21.
This is virtually the only "graphical hook" in the entire document and it is working nicely here.
I think I would definitely use a larger gutter, and somewhat larger L/R margins to account for page creep.
The index page is a bit too "L-A" for my tastes, but some clients really dig this kind of formatting quirkiness.
Having said that, I think this attempt looks slightly stilted and out of place in this layout. (much like the web 2.0 junk)
Good opportunity to establish a subtle graphical theme for the rest of the pages.
K.I.S.S.
GL