Have you installed anything new lately? I had some image corruption once because I installed something and a reinstall of 10.5.8 fixed it (I was running Leopard).
It could also be heat. With my Quad G5, unless I remove the ATI graphic card drivers I'll get fritzy pixel spots all over the display and the Mac will stop responding to commands. I have not yet gotten to repasting the GPU but I believe it's heat related.
Does this go away after some time?