I have an iPhone 5 and was wondering what the best way is to get my iPhone 4S data/apps which is running iOS 5.0.1 onto my iPhone 5? Backup via iTunes and do a restore from a backup? Will this screw up since the iPhone 5 is running iOS 6?
Just do the backup and restore on your iPhone 5. You can restore up a version but not backwards (as in 5.1 to 6 is fine. iOS 6 to iOS 5 won't work) if that makes sense.