Become a MacRumors Supporter for $50/year with no ads, ability to filter front page stories, and private forums.
I use Skype regularly. It's just a beta, so there's lots of bugs and the program is a memory hog. It still has fantastic voice quality. It's like the other person is in the same room as you. I don't use Skypeout, because my home phone is VOIP and it's actually cheaper for me to use that.
 
Register on MacRumors! This sidebar will go away, and you'll see fewer ads.