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macrumors 6502
Original poster
Not through Simplify Media, it doesn't connect to either of the two sources you can currently use.
You can however stream Sirius to your iPhone using a combo of uSirius and Orb (or TVersity) on a PC.
uSirius makes a native iPhone app, but its only available to jailbroken iPhones at the moment. Also, NiceMac is hard at work on one as well.