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I don't think they would be there if it wasn't safe ;)
OnyX does tell you to make sure your computer's backed up before you do anything, however every time I've deleted my caches in OnyX I haven't had any problems (I clean them a lot - I'm a freak about that).
 
1. Kernel
2. CUPS Jobs
3. Directory Services
4. Audio Units

Safe to remove using Onyx? Thanks.

You can remove practically any cache in the system and it will be rebuilt after reboot. I know for a fact that you can safely clear out ANY of the caches from within Onyx and have no odd side effects, if you reboot when it tells you to.
 
Yes, they're safe to remove -- but I wouldn't bother unless you have a specific reason for doing so.
 
I use yasu to clean my caches and actually see a speed boost. What was previous posted, back up in case something goes south.

Really? The point of caches is to speed up information acquisition, I would have expected any speed boost to only be a matter of perception. <shrug>
 
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