Should probably clarify it as "people who wear their Watch on their Right Hands" because I know some lefties still sport it on their left hand, and some right handers wear may wear it on their right.
That said, I'm a lefty and wear it on the right. Digital crown on the bottom left facing my hand. I feel the main reason this even comes into question really, is because Apple's marketing is towards wearing the Watch on the left/having the digital crown on the upside above the side button. That may be obvious, but the point being, the reason it looks weird/off/"wrong" when having it on the lower side is because all we've seen is it the other way around. It takes hardly any time to get use to the look and feel of it on the bottom left, and it's way more convenient than trying to use it "away" from your active/working hand, IMO.