I use it in os x and dont' have any issues. Mind you I don't use it often, not because there are better programs, just because I've never been a heavy p2p user.
I don't like Limewire now at all. I mostly use Google's blog search to find what I'm after If you want a P2P programme I think SoulseeX is pretty good.
I used to use Frostwire, but when I upgraded to Leopard it quit connecting
So now when I need to download anything from P2P I open Ares Galaxy in Parallels and download it from there. I wish Ares Galaxy was developed for OS X, and not that crap they consider to be it in Poisoned
IMO limewire is excellent. almost always find single items, but bittorrent for larger things is definitely better. killer dl rates with limewire, like over 300kbps consistently.