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What Apps do you run? I am using 4GB of RAM right now and my most power hungry apps right now are either Team Fortress 2 and Left 4 Dead. With these open I still have around 800MB to 1GB of RAM left.
 
Does Activity Monitor report a large number of Page Outs over a relatively short period of time? Do you see a significant amount of Swap used? If so, then yes, you should see a speed increase. Otherwise: No, not really.
 
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