The question I _think_ you're asking, though, is related to running 16 tracks of synths/virtual instruments (which are played/respond to MIDI). The short answer is yes, absolutely. The much more correct answer is that it depends on the synths/instruments you are running, how you run them, and the bit rate and depth in which you run the session... Some VI's can command all your system resources (ex. omnisphere) if you set them up correctly, while some are very lightweight. You'll just have to find out.