I am not familar with the phrase, "Have you repaired permission". I am also not sure whether or not I have the latest version of digi core audio either. All I know at this point is, Garageband works fine with out the m box hooked up, and crashes when it is hooked up, even if just playing a song that i had written prior to using m box. But I will look into the permission thing and the core audio version. ProTools itself seems to play the demo ok without crashing, i haven't actually used this software yet to record. And Reason works fine, again, unless the M-box is hooked up, and then it crashes just on playback.
Thanks to both responders for your help.