Mail icon bounces once and does not open

[marywm]

When I log onto my MAIL icon it just bounces once and does not open. Same goes for Safari HOWEVER the Firefox, Excel, Word icons open.
I have tried re-booting but no luck. As a back up I am using Entourage for my email but prefer to use MAIL, as well would like to use Safari again! What do I need to do to get these working again?

 

[BlueRevolution]

Can you open Console? (/Applications/Utilities/Console.app) Do you see anything unusual in the logs?

 

[marywm]

Ca't open up console

 

[JediMeister]

If you have not already checked, run updates for your system from the Software Update option under the Apple menu. If there are any for Mac OS X or Safari, install them and check if the issues persist. You should be running 10.5.8/10.6.2 and Safari 4.0.4.

 

[BlueRevolution]

What about  -> System Preferences?