I breifly had one on my iphone 4 and there was a noticable difference in picture qulaity. I would imagine the new iPad would be similar. If you are hoping that the matte screen would make it easier to view in sunlight, the tradeoff isn't worth it.
The matte screen protector will affect the clarity of the screen. So it's a trade off, if you want less fingerprints, less gloss, you'll lose the beauty of the new screen.