I suppose after years and years of use, you might see some wearing on the finish where you use a mouse (if solid wood). We've got some cubicles at work that are HQ veneer, that seem...glossy I guess would be the best way to describe it...where a mouse was used. It doesn't really look bad, in fact, the area that was worn down is like a sweet spot for the mouse. It's like gliding on ice.
My cheap white iKea desk at home has sort of a rough texture to it that causes the mouse to feel like it's running over sand and produces a pretty obnoxious sound. Mouse pad is required for me at home .
I have several of these - one for each workstation. They are thin, slightly textured and have a great feel. Check for other sizes and shapes - round, rectangular, etc.