Granted, high ISO performance can somewhat (in theory) offset fast glass, except where autofocusing is concerned. AF can be problematic at f-stops close to 5.6 in darker environments (which is where most cheaper variable aperture zooms are on the long end,) not to mention bad visibility in the viewfinder for manual focusing if need be. Also, to get that kind of high ISO performance you'd have to spend close to $5000 for the body alone... and then to pair it with cheap lenses would seem almost foolish, at least in my opinion. So, for the current situation, I still think fast primes and perhaps an 11-16f/2.8 zoom like Tokina's for wider, stylish stuff. The real problem is that f/2.8 isn't really fast enough for lots of these scenes in nightclubs unless using strobes, which wasn't discussed. It can be adequate, but f/1.4 is certainly going to up the "keeper" rate even at ISO 1600-3200. Perhaps the ideal prime might be the new 24mm f/1.4, but again, not cheap. Cheaper than a D3s, though, by a mile. And it would not depreciate nearly as fast.