1. red is too bright, match it with the tab on the cancer society logo.
2. drop italics on everything EXCEPT the caption at top, and text above and below logo.
3. I would place "That's why I urge you to donate..." below "...and he needs your help."
4. the bottom image looks better IMO, anti alias your text (are you using photoshop? it's under the text options, i like sharp or crisp).
5. soften the logo's drop shadow, it's too hard.
6. organize. it looks like everything was tossed onto a photoshop document and then dragged into place. Some text is too large, others too small.
7. you should add the word "charity" to the end of your little blurb, it was confusing the hell out of me for awhile until I assumed that's what was supposed to go there, don't assume your target audience knows anything, they usually don't.
8. reconsider a font sans serifs. they make things seem too congested when they really aren't. also the top image, text is chunky, bottom image it's blurry, anti aliasing is key

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9. i dont know what the grey text under ACS logo is...but it's illegible so is unnecessary.
quick edit of how i'd arrange it, it still needs resizing and all the other touch ups, just thought i'd give my input
