As I understand it, the update prebinding routine has a visible effect only after something significant changes in the software setup.
That is why OS updates, and complex software installs show 'Optimizing' before exiting. If you have been following the OS update routine, or have installed software recently, chances are your prebindings don't need updating.
The best ways to speed up OSX (from a software perspective), are to make sure you have no orphaned processes, make sure you have all system daemons you aren't using turned off, and logout every few days to kill anything not owned by the OS.
On thing you should check if you have to reboot is disk consistency. An orphaned node, or incorrect file count can cause slowdowns as the OS searches for a record. Your can check and repai an OSX disk by booting in single user mode, waiting for the prompt, and typing fsck -y. When fsck -y reports the disk is healthy, type reboot.
Unless you see a speed decrease, there is not a lot you can do to create a speed increase. OSX is a lot better at maintaining itself than Mac users are used to, so in some cases preventative maintainence won't help, and in more severe cases preventative maintainence can cause harm.
