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Outside of a few tweaks now and then with Onyx, my little baby (well, okay not little) has never given me a glimmer of trouble.

So, no. Not really.
 
Not needed. OSX has no registry and has no windows registry problems.

OSX also auto defrags files of certain size and under.
 
I too was wondering this. Having had my Mac Pro for a while now. It does seem a little sluggish these days. Photoshop and the such are not running like they did.

I know on my windows box I used to run a program called atf cleaner. I have plenty of disk space etc.

Anything you guys can recommend? On a side note I have close to 400 fonts installed on my main machine. Was wondering if that could possible be an issue but 400 does not seem a like a lot to me. Could be wrong.
 
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