BareFeats tested the unibody MBP with 6 GB and 4 GB. The goal was to find out if unmatched DIMMs would lead to a considerable performance decrease. What they found was that it didn't.
But of course if somebody has 4 GB and is paging out to disk he/she should get 6 GB immediately. Paging out to disk makes memory i/o orders of magnitude slower. Not 0.8% like the unmatched DIMMs, but something around a factor 1000. Obviously if 4 GB are enough you don't need to go unmatched. But if you page out at 4 GB, there is absolutely no reason not to go to 6 GB.
"The 6GB configuration produced essentially identical benchmark results to the 4GB configuration in our 2.8GHz MacBook Pro. The difference ranged from -.5% to +1.7% or an average difference of +.28% or less than 1/3 of one percent. I call that negligible. Or, in other words, you should have no worries about a speed penalty imposed by non-matching memory modules and loss of interleaving.
And when you consider the 6GB configuration potentially means less virtual memory swaps, then the only consideration is the cost. Maybe instead of ordering your MBP with the $500 128GB SSD, you should save your money for a 4GB memory module.
Looks like a winning combination to me. You can never be too thin, too rich, or have too much memory."