As others have said, it depends on the school. Definetly ask them and also check the course requirements.
It's been a long time since I graduated but in my day Information Systems degrees were more focused on systems analysis and design for your typical, large corporate systems. I was a MIS major. We learned some programming but also learned database design, decision support systems, expert systems and some data communications.
At Penn State MIS was in the business school and also gave you exposure to management, accounting and marketing courses.
Comp Sci degree was in the Sciences school / department and tended to focus more on programming and lower-level stuff. I had friends in CompSci and they designed their own compilier and maybe even an OS kernel. Also being in the Sciences, the degree requirements changed (more calculus).