Last weekend I was futzing with things on my MacPro and suddenly the USB ports stopped working. And I mean ALL of them. Was all set to eBay a new MP when I figured out how to reset the ports.
Some background: The night previous I was copying items from an internal drive to a USB 2.0 drive. I left the operation to run overnight (it was about 800gb). I came down to find a file copy error. So, I tried again, but then decided to abort. When I aborted is when the problems started. Finder became unresponsive, had to reboot and then ran into a prohibitory boot situation. I couldn't select a different drive to boot from because the ports were out.
In my case, I think what happened is that the USB drive enclosure failed during the copy process. Either that or it just overloaded and dropped out. I don't trust it now so it's been disconnected from my system since and I've had no further problems.
I know your issue is FW, but this is a long-winded way of saying the following: check your attached FW devices. From this past experience they can go down and go down hard. If you still trust your optical drive I think the best bet might be to leave it disconnected until you actually need it.