I believe that all Apple apps (native OS X apps, anyway) will now run on UFS. That didn't used to be the case. However there are two problems with UFS. The first is that OS X apparently takes a performance hit when the disk format is UFS. Second, some third-party apps will not run on UFS, even though there's no good reason for that. One of the Microsoft apps I have - either Office v.X or Virtual PC 6.1 - will not work properly on UFS. I used to have my /Users directory on a UFS partition and found that the app (I'm pretty sure it was VPC) gave me a warning when I tried to save to that partition.