But 1680*1050 WILL look better on retina then on a native panel, because its rendered at 2x and essentially "downscaled" to retina, meaning you don't see pixels anyway.
If you look back at the original question it was whether you would "lose clarity" by using "more space" rather than "best for retina" on a retina display. The "native 1650x1050" panel thing is a bit of a red herring.
All the "more space" modes involve rendering to a virtual screen and then scaling by a non-integer factor. It is that additional, non-integer scaling that is
always going to reduce quality compared to direct, "smart", rendering at 2880x1800.
In 2880x1800, your "512x512@2x" icon will get rendered 1:1 at 1024x1024 pixels as nature intended.
In "1650x1050" mode, it will first get rendered to the 2x virtual screen as 1024x1024 and then re-sized to 894x894 on the "real" screen. That will inevitably be degraded compared to either a 1024x1024 icon rendered 1:1 to a retina screen, or for an icon
designed to be rendered at 894x894.
If you have a non-retina app, which uses an old-school 512x512 icon then (unless OSX is really, really clever)
first that will get upscaled to 1024x1024 by the OS, then it will be scaled again to 894x894. Again, that is an extra step that will introduce more "artefacts" than directly upscaling 512x512 => 1024x1024 in "best for retina" mode. That scenario could - depending on the content and how the application did its rendering - even conceivably produce a worse result than a real 1650x1050 panel.
leman said:
I mean, printers, cameras etc. all do some sort of interpolation (explicit or implicit e.g. via the camera lens) to map the 'real' HiDef image to the limited resolution of the medium (e.g. camera sensor)
...and that's one reason why serious photographers prefer RAW mode, so that their post-processing can use the original, un-interpolated data direct from the sensor rather than something that has already been interpolated once in the camera, minimising the number of interpolating/re-sampling steps.
Its why you shouldn't scale all your artwork to 600dpi before printing - a decent printer driver will make a better job of interpolating/resampling the original data, optimised for the characteristics of the output medium.