I've been using an Intel 80GB X25-M for several months and I certainly don't notice any slow down. I'm only using about 20GB of it. I did install the latest firmware upgrade, but I don't know of a way to determine whether TRIM is at work or not.
I haven't noticed any slowdown either, but look at my Xbench score below... The random writes have slowed down dramatically. I hope a maintainance tool will becoma available for osx asap.
I bought my macbook about 6 weeks ago, and put an Intel x25-m in it right away. I have 30GB in use (out of 80GB), I don't use any applications that make heavy use of a harddisk, but have been using the notebook 4-5 hours a day on average.
On the day I bought it:
Disk Test 222.20
Sequential 139.61
Uncached Write 139.37 85.57 MB/sec [4K blocks]
Uncached Write 122.37 69.24 MB/sec [256K blocks]
Uncached Read 92.90 27.19 MB/sec [4K blocks]
Uncached Read 393.80 197.92 MB/sec [256K blocks]
Random 544.03
Uncached Write 656.52 69.50 MB/sec [4K blocks]
Uncached Write 238.96 76.50 MB/sec [256K blocks]
Uncached Read 1717.59 12.17 MB/sec [4K blocks]
Uncached Read 941.28 174.66 MB/sec [256K blocks]
Today, after installing the new firmware:
Disk Test 214.21
Sequential 169.24
Uncached Write 144.17 88.52 MB/sec [4K blocks]
Uncached Write 139.99 79.20 MB/sec [256K blocks]
Uncached Read 140.89 41.23 MB/sec [4K blocks]
Uncached Read 407.08 204.60 MB/sec [256K blocks]
Random 291.73
Uncached Write 167.51 17.73 MB/sec [4K blocks]
Uncached Write 163.42 52.32 MB/sec [256K blocks]
Uncached Read 1686.65 11.95 MB/sec [4K blocks]
Uncached Read 971.56 180.28 MB/sec [256K blocks]