I wouldn't assume it's the retina display. Adobe Reader has had long-term performance issues on OS X, even before Yosemite. This is very confusing because there are several different ways a PDF can be displayed. The most problematic is Adobe's plugin for Safari:
(1) Mac OS built-in PDF preview. Access by: selecting PDF in finder, press space bar. Page up/down by: Fn + up/down arrow keys. Result: always fast.
(2) Stand-alone Adobe Reader. Access by: double-clicking on PDF in finder (if Adobe Reader is default app for this file type). Otherwise, drag/drop PDF to Adobe Reader icon. Page up/down by: Cmd + up/down arrow. Result: relatively fast; they may have improved the performance in the latest version.
(3) Adobe Reader plug-in for Safari. Access by: open PDF from Safari, or drag/drop local PDF to Safari. Result: slow page up/down. Solution: remove Adobe plugin files and revert to Safari's built-in Adobe rendering.
Detailed discussion:
https://forums.adobe.com/message/5605530#5605530