Be aware that doing some very simple file moving can result in HUGE TM backup sizes.
Example - you download a bunch of images from your DLSR memory cards to your desktop - say 16GB or so. Before you do anything with them, you pack it in for the night. Time Machine backs up your 16GB of files while you are asleep. The next day you move them from your desktop into your Pictures folder. Maybe you sort through them there and cull out 2GB or so, so now down to 14. Later on, that 14GB gets written to TM. Then, you import those 14GB of images into your iPhoto app - iPhoto moves them from your pictures folder into the iPhoto Library, and also creates previews of them (which can be 5MB per image depending on your preferences). Later on, TM backs up those 14GB of images and maybe another 4GB or so of previews. So, for the 14GB of images that you put into your iPhoto Library, TM is storing 49GB worth of images all in different locations.
Changing a folder name or location of a folder with lots of files in it can have a similar effect.
There is an app called Time Machine Perspective (which is based off of Grand Perspective) which lets you visually see the files on your TM drive and look for large chunks of files that TM has only backed up once. The premise is that if you move a file around just after a TM backup, you probably want to remove it from its original location but keep backing it up from its new (and hence current) location.
I use this every few months or so to keep my TM backups manageable.