I recently downloaded TrimTheFat and have used it on my Mid-2007 MacBook to eliminate some PPC coding from programs. I was wondering whether or not it would be safe to use, like many do with Xslimmer, on Mac OS X's core programs (Mail, iTunes, iCal, etc.) or the iLife & iWork suites.
I personally would not. Used it on Word '08 and had trouble with updating the software later down the road. Had to reinstall and download half a dozen updates (200mb a piece it seemed). Ugh...