Hate it that much?
Sometimes, I know exactly how you feel...
First, tell us if you're using Quark 5 in Classic or OS9 OR... Quark 6.x on OS X.
If it's OS X, then that's easy. Trash the Quark application folder, then trash the Home>Library>Preferences>Quark folder.
There may still probably be some stray printer descriptions lurking about but you don't really need to worry about those as they hardly take any space up at all...