As others have stated I would suspect the activity to be normal
Spotlight indexes
Virtual memory (pages in, pages out)
iTunes activity
Activity of other programs.
OS X will work to journalize and defrag the system in the background while you do other work, if it sees the need to do so.
How much memory does your computer have?
::EDIT::
How about shutting down some of those Widgets? Perhaps them going out to the internet for updates constantly is causing them to write data into their own separate caches.