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you may have to hit restore in iTunes to download official release as it will detect iOS 6 on your device and say your up to date if you hit check for updates. I went from beta 6 to GM no issues.

Remember always backup before updating ;)
 
You'll need to option-update via iTunes, but you don't need to do a full restore.
I said hit restore so that iTunes would download iOS 6 you can easily unplug device during download
doing option-update does not download iOS 6


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Would it be safer to back up to iCloud, or iTunes?
up to you, for me I always find it convenient to do it via PC as it's quicker for apps to be synced
 
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