I don't see how the ratio would make a difference unless you plan on holding it in one hand between your thumb and fingers--something I wouldn't expect to do on a tablet this large.
I find holding my iPad Air one-handed very comfortable and this tablet is even lighter. I find 4:3 a far more usable display ration on a tablet--much more usable space in both orientations. The only knock is that you'll have black bars when watching video but is that truly really a problem, considering the video will use the same number of pixels.