So I'm assuming this is a software problem although I guess it could be a hardware issue just starting. Whenever my computer wakes up from sleep the volume icon in the top is greyed out and the volume buttons don't work to change the volume. If headphones are plugged in the volume control works for them, and a restart fixes it for the built in speakers until the next time the computer sleeps.
I'm attaching a screenshot so you can see what I'm talking about.
I'm attaching a screenshot so you can see what I'm talking about.