I have an iPad 2 wifi 64GB and it has replaced my desktop and laptop. For work all my training videos, presentations, technical manuals, e-mails, video conferencing, invoice tracking, and some of the hospitals I visit are using iPads for patient medical records and administration. I use LogMeIn Ignition, DropBox, NotesPlus, GoodReader etc.
At home I use my iPad to watch YouTube videos, Netflix, surf the web, organize soccer training with videos, kids homework, Facebook, share photos, read books, listen to audiobooks, stream music from iTunes.