if you're doing graphics stuff, i'd say go for it just because it's the most bang-for-buck upgrade on the device honestly
i got the 460 GPU, but stuck with the base 2.6 i7 CPU in the 15" just cuz i don't think +100mhz and +2mb L3 cache is actually gonna matter for $150 extra bucks.
and for those complaining about RAM issues in general, the 460 has 4GB of RAM on it, which is just a huge step up from previous macbook pro GPU options
the objective measure to take into account is: do you use a lot of textures in your graphics? are there images baked into the design or whatever you're doing? because that's where the extra vRAM will shine – when the computer can have all the textures and overlays and images ready to go for editing