50 GB is no longer that much space. Is suppose you get it by increasing the platter (disk) radius, compacting the data, or adding another platter, all of which sound pretty cheap. But to increase the speed, you probably need a better motor and bearings, which must cost a lot.
The main advantage of more speed is that it takes less time to access the disk. The advantage of this becomes evident when you are loading large applications, reading large files, or copying large files from place to place. And I'm not sure how fast USB has gotten, but it may also decrease the time it takes to copy/move files between flash or other external devices and the computer. If you plan to be working with large files or doing a lot of interacting with the disk, you probably want higher speed. In my opinion, it's not worth it.